Abstract :
Background: Conventionally, carcinomas of the ovary have been thought to arise de novo from the ovarian surface. However recent studies have indicated that putative ‘precursor’ changes are present in the fimbrial ends of fallopian tubes.
Aims: The study was aimed to identify histological changes in the fimbrial ends of fallopian tubes across three sets of patients.
Settings and design: Histological sections from fimbrial ends of fallopian tubes from a total of 14 women who underwent prophylactic salpingo-oopherectomy for non-neoplastic diseases, twelve who were treated for non-serous ovarian carcinoma and nine consecutive cases of ovarian serous carcinoma cases over a three year period from a tertiary care hospital were studied.
Methods and Materials: Sections were stained with hematoxylin-eosin and p53 immunohistochemical staining.
Statistical analysis used: One-way ANOVA (Analysis of Variance).
Results: Histological changes in the fimbriae ranging from SCOUT to STIL and STIC and p53 signatures were found across all three populations but were multifocal and significantly higher in cases of ovarian serous carcinoma.
Conclusions: Our study identified statistically significant differences in histological changes and p53 immunostaining in the fimbrial end of fallopian tubes across three populations of patients.
Keyword :
Ovarian serous carcinoma, Fallopian tube, Secretory Cell Outgrowths (SCOUTs), Serous Tubal Intermediate Lesions (STILs), Serous Tubal Intraepithelial Carcinoma (STIC), p53 signatures