Abstract :
Purpose: To study progression of primary open angle glaucoma in patients with maintained target
intraocular pressure.
Materials and Methods: This was a prospective observational study comprising 30 diagnosed patients
of primary open angle glaucoma on maintained target intraocular pressure conducted for a period of 2
year. Patients underwent complete ophthalmic examination including IOP, optic disc evaluation & visual
fields. Systolic and diastolic blood pressure was measured with sphygmomanometer using adult cuff size.
Systolic, diastolic & mean ocular perfusion pressure ocular perfusion pressure were calculated. Patients
were examined at baseline then at 12 months then at next 12 months. Progression of glaucoma was accessed
on the basis of changes in VF ’ s &optic disc between baseline and final follow at 2 years. Data analyzed
using standard statistical technique and a probability value ( ‘ p ’ value) of < 0>
statistically significant.
Results: Mean age of study participates was 540.07 years ,M:F ratio was 1.5:1.Progressive patients
showed significantly changes in optic disc cupping C:D ratio f0.670.11gat baseline tof0.740.13gfinal
follow up (p
up(p
progressive group. DBP, DOPP and MOPP were significantly lower in progressive group as compared
to non-progressive group.
Conclusions: Low DBP, low MOPP, and low DPP are risk factor for primary OAG progression with
maintained target intraocular pressure, providing further evidence of a vascular mechanism in glaucoma
pathogenesis
Keyword :
Primary Open Angle Glaucoma (POAG), Visuals Fields (VF), Mean Deviation (MD), Patterned standard deviation(PSD), Cup Disc ratio (CD), Systolic blood pressure(SBP), Diastolic blood pressure(DBP), Systolic Ocular Perfusion Pressure(SOPP), Diastolic Ocular