Abstract :
Introduction: The routine antibiogram is a profile of antimicrobial susceptibilities which by using various parameters and stratifying the cumulative susceptibility help achieve enhanced or stratified antibiogram. Stratified antibiogram help guide empirical therapy for the selected patient groups.
Materials and Methods: The annual susceptibility data of blood culture isolates, where ?30 isolates were available from January to December 2023 were compiled and the first isolates were filtered for various parameters such as syndromic, location, HA/CA and broad specialty in alignment to the standard CLSI M39 guidelines. The susceptibility was then calculated using a ‘Clinical Microbiology Reporting software’ and represented as S% - susceptibility percentage.
Result: The one-year study period, includes 2853 “first-isolates” that comprised of both gram-negative bacilli (GNB) and gram-positive cocci (GPC) blood culture pathogens. Analyzing syndromic antibiogram it is depicted that E. coli and S. aureus stand out as the major pathogen among GNB and GPC respectively. Enterobacterales (ENB) were found to have high resistance to third generation cephalosporins and A. baumannii complex had the least group of antimicrobial classes susceptible. The enhanced antibiogram of the major gram-negative pathogens from BSI showed that in general ICUs had more antimicrobial resistant (AMR) isolates, and HAI isolates were more resistant than CAI isolates. These differences were most evident in K. pneumoniae followed by P. aeruginosa.
Conclusion: Preparation of a Multi-stratified antibiogram such as BSI ICU antibiogram or BSI medicine antibiogram will be of utmost help in guiding correct empirical antimicrobial decisions if significant isolate number can be obtained.
Keyword :
Sepsis, Routine Antibiogram, Empirical therapy, Syndromic antibiogram, Stratified antibiogram, Susceptibility