Abstract :
Gastro retentive drug delivery system (GRDDS) is one of the novel approaches in the area of oral sustained release
dosage forms. Drugs that are easily absorbed from gastrointestinal tract (GIT) and have short half-lives are
eliminated quickly from the systemic circulation require frequent dosing to achieve suitable therapeutic activity.The
floating drug delivery systems increase the Gastric retention time providing wide therapeutic efficacy.
Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and
mucin molecules and increase the residence time of the dosage form at the site of absorption. The drugs which have
local action or those which have maximum absorption in gastric pH require increased duration of stay in GIT. Thus,
floating and mucoadhesive drug delivery systems are advantageous in increasing the bioavailability and enhanced
therapeutic activity. In this regard, this review aims to provide information of different floating and mucoadhesive
approaches and their importance.
Keywords: Bioadhesive, floating drug delivery, gastroretentive, mucoadhesive
Keyword :
Bioadhesive, floating drug delivery, gastroretentive, mucoadhesive