Abstract :
Alzheimer’s disease is the most prevailing type of dementia worldwide with pathological hallmarks as
neurofibrillary tangles and amyloid β plaque. A large number of research and studies are undergoing to determine
the exact pathophysiology of the disease which may further lead to development of better treatment strategies. Based
on the existing hypothesis a number of treatment and management therapies are utilised for prevention and control
of disease. Conventional therapies based on AChE inhibitors (Donepezil, Rivastigmine and Galantamine) and
NMDA receptor antagonist (Memantine) are most effective and frequently used but are only capable of controlling
the disease progression and are not capable of treating the disease completely. New therapies include disease
modifying therapies based on the concept of reducing the functioning of secretase enzymes which is primarily
involved in conversion of APP into amyloid β plaque. Other promising therapies based on different hypothesis
include the use of insulin, antioxidants, stem cell and also various herbal drugs which show remarkable decrease in
progression of disease. This review also includes a number of compounds which are under different phases of
investigation and clinical trials and may be used as an important tool for treatment of disease in near future.
Key words: Alzheimer’s disease, APP, APoE-e4, Biomarkers, Secretase Inhibitors.
Keyword :
Alzheimer’s disease, APP, APoE-e4, Biomarkers, Secretase Inhibitors.