Abstract :
Matrix metalloproteinases (MMPs) are a group of zinc-dependent enzymes that play a critical role in the degradation of extracellular matrix components, including collagen, elastin, and proteoglycans, making them central to tissue remodeling processes. In the context of periodontal disease, MMPs are key mediators of connective tissue breakdown and alveolar bone destruction, driven by chronic inflammation. This review focuses on the role of MMPs in periodontal disease, highlighting their regulation, activation mechanisms, and the interplay with inflammatory cytokines such as interleukins and tumor necrosis factor-alpha (TNF-?). Furthermore, the review discusses the contribution of specific MMPs, including MMP-1, MMP-8, and MMP-9, in periodontal tissue degradation and explores potential therapeutic approaches to inhibit MMP activity to prevent periodontal disease progression. By understanding the molecular basis of MMP involvement in periodontal pathology, this review aims to provide insights into novel therapeutic strategies aimed at mitigating connective tissue breakdown in periodontal disease.
Keyword :
Periodontal diseases, Connective tissue breakdown, Inflammation, Matrix metalloproteinases(MMP)