Abstract :
Objective: This study aims to evaluate the efficacy of a cocktail regimen for the treatment of sudden sensorineural hearing loss (SSNHL).
Design: A prospective observational study.
Setting: Tertiary care hospital.
Participants: Thirty-five patients diagnosed with SSNHL who met the inclusion criteria.
Intervention: The cocktail regimen included intratympanic steroid injections, oral steroids, valacyclovir, and pentoxifylline.
Main Outcome Measures: The primary outcome was the change in Pure Tone Audiometry (PTA) from pre-treatment to 3 months post-treatment, analyzed by Modified Siegel’s criteria.
Results: Of the 35 patients, 26 (74.2%) showed hearing improvement (including complete and partial recovery) at the 3-month follow-up. The mean improvement in PTA was 22.56 dB (SD = 18.4). However, the calculated odds ratios (OR) for treatment efficacy and hearing recovery comparisons were 1.0, with wide confidence intervals, indicating no statistically significant differences between improved and not improved groups.
Conclusion: The cocktail regimen showed potential benefits for hearing recovery in SSNHL patients, particularly in cases with less severe initial hearing loss. Nevertheless, the absence of a statistically significant difference in the comparative analyses underscores the need for larger, randomized controlled trials to substantiate these findings.
Keyword :
Sudden sensorineural hearing loss, Cocktail regimen, Hearing recovery