Abstract :
Human immunodeficiency virus (HIV) infected individuals are always at an increased risk of malignancy. This goes well with regard to AIDS (Acquired Immunodeficiency Deficiency Syndrome) defining malignancies such as Kaposi’s sarcoma, Non-Hodgkin lymphoma and invasive carcinoma of the cervix, and non-AIDS defining/AIDS-associated malignancies like Hodgkin’s lymphoma anal carcinoma and squamous cell carcinoma. Usually solid malignancies are noted in HIV patients. Among hematological malignancies, chronic myeloid leukemia (CML) has rarely been described in association with HIV-infection. Till date, less than 50 cases have been reported in literature. Majority of these reported cases are from African continent. Our patient was a 45-year old female with this dual pathology and presented with pain abdomen, hepatosplenomegaly and high-grade fever. CML can be considered as a rare AIDS defined hematological malignancy. Timely diagnosis can help in initiating dual treatment for HIV & CML, thereby preventing grave complications in such patients. This paper is an attempt to review the pathogenesis behind this association.
Keyword :
CML, HIV/AIDS, Hematological malignancy, TKIs, Imatinib