Abstract :
Background: Phyllodes tumor (PT) accounts for 0.3-1% of all breast tumors and classified into benign (BP), borderline (BLP) and malignant (MP). However, grading system is somewhat subjective and diagnosis remains challenging. Ancillary techniques may help in classification and prognostication of the tumor.
Aim & Objective: Evaluation of the proliferative activity by Ki-67 index in Indian scenario.
Materials and Methods: 50 PTs received from January 2014 to December 2018 were graded using WHO criteria 2019. Ki-67 labelling index (LI) was calculated and graded 1 (1-35%), 2 (35-70%), 3 (70- 100%). Relevant statistical analysis was applied. P value of
Results: 70% (35) were BP, 26% (13) BLP and 4% (2) MP. Infiltrative margin, increased stromal cellularity, overgrowth, nuclear atypia and mitotic index were significantly associated with higher grade (P
Conclusion: Histopathologic characteristics correlated with Ki-67 index. However, it was uncertain whether Ki-67 could provide independent prognostic information beyond histopathological typing. Continued follow-up with greater number of significant episodes may yield more informative correlations.
Keyword :
Ki67 labelling index, Phyllodes, WHO grading