Abstract :
Background: The fungal infections are increasing at high rate especially in immune-compromised patients and elderly population. In high risk population, antifungal resistance is becoming a major concern. Antifungal susceptibility testing is important for appropriate management and better outcome of patients.
Aim: The aim of the study was to know clinico-Mycological profile of fungal infections in admitted patients.
Materials and Methods: This prospective study was carried out in a tertiary care hospital. Various samples were received from patients with suspected fungal infections. All samples were inoculated on SDA except blood & body fluids which were directly inoculated into blood culture bottles and processed in BACTEK/BacTAlert system. Fungal infections were characterized and antifungal susceptibility was done for yeast isolates with VITEK-AST panel.
Results : Out of total 19698 patients suspected of fungal infection, fungal infection was seen in 365 patients , 100% susceptibility was seen to Fluconazole and Echinocandins. Whereas in NAC (non-albicans ), 72.5% susceptibility was seen to fluconazole and Voriconazole (82.5%).
Conclusion: Antifungal resistance is major cause of morbidity and mortality. Prompt diagnosis and antifungal susceptibility will offer the early appropriate treatment and better clinical outcome of patient.
Keyword :
Fungal infections, Antifungal susceptibility, Candidiasis, Aspergillosis