Abstract :
Hypertension results from increased peripheral vascular smooth muscle tone which leads to increased arteriolar
resistance and reduced capacitance of the venous system. Elevated BP is an extremely common disorder and many
of the individuals have no symptoms. Chronic hypertension either systolic or diastolic can lead to congestive heart
failure, myocardial infarction, renal damage and cerebro vascular accidents. The beta blockers are used
individually or in a combination therapy to treat hypertension. The development of oral osmotic systems has a
strong and good market potential. Atenolol is a cardio selective beta-1 blocking agent which is used to reduce
systolic and diastolic B.P and it is widely used to treat hypertension, introduced in the year 1976. It reduces heart
rate and cardiac output when resting and during exercise. The osmotic drug delivery system utilises the principle of
osmosis and drug release is aimed to release by zero order kinetics, to prolong the release of the drug for longer
duration of time, providing the treatment in controlled manner by reducing the multiple dosing of drug.
Keywords: Atenolol, Beta -1 blocking agent, Diastolic, Hypertension, Systolic, Osmotic, Zero order.
Keyword :
Atenolol, Beta -1 blocking agent, Diastolic, Hypertension, Systolic, Osmotic, Zero order.