Abstract :
Cinnarizine is a H1 anti-histaminic drug and it can be used in the treatment of nausea, vomiting, motion sickness,
vertigo and in menier’s disease. The purpose of present work was a development of fast dissolving oral film of
cinnarizine, to overcome the limitation of current routes of administration to provide faster dissolution rate and
increase the patient compliance. The amount of dose of drug calculate according to the area covered by the 15ml
formulation without drug. The amount of drug was then used for the preparation of film by using solvent casting
method utilizing HPMC E5 as a film forming polymer and PEG 400 as a plasticizer. The 32
factorial design was
applied for optimization of concentration of polymer HPMC E5 and plasticizer PEG 400. The prepared film were
evaluated for various parameters like film thickness, folding endurance, drug content, dispersion test, uniformity of
weight, surface pH measurement, moisture loss study, in vitro drug dissolution study, disintegration time and
stability study.in vitro drug dissolution studies were carried out using simulated salivary fluid (pH 6.8 phosphate
buffer).among all the formulation, formulation (F5) which contain HPMC E5 (15%)and PEG400( 6%) were
released upto 98.17% of the drug from the film within 25 sec. which exhibit faster absorption and also shows
desirable characteristics of film than other formulation.
Keywords: Oral fast dissolving film, cinnarizine, motion sickness, menier’s disease, HPMC E5, PEG 400, solvent
casting
Keyword :
Oral fast dissolving film, cinnarizine, motion sickness, menier’s disease, HPMC E5, PEG 400, solvent casting