Abstract :
The aim of present work is to formulate and evaluate buccal tablets of protonix (pantoprazole sodium) which is
subjected to first pass effect and having short half life. To increase the bio availability of a protonix by delivering
through the buccal mucosa, as it is a potential site for direct delivery of drugs into systemic circulation. To control
the drug release from the tablets by using matrix forming bioadhesive polymers, as the half life of drug is very low.
To study the effect of drug : polymer ratio on drug release and other bioadhesive properties.
Key words: Buccal, Protonix, Bioadhesive, Systemic circulation, Half life
Keyword :
Buccal, Protonix, Bioadhesive, Systemic circulation, Half life