Abstract :
DNA cleavage potential of 4-(piperidin-1-ylmethyl)-2-(thiophen-2-yl) quinoline 7(a-j) derivatives, were studied on
Calf-thymus DNA by agarose gel electrophoresis method. The compounds 7e and 7j have exhibited almost complete
cleavage, whereas the other compounds 7a, 7b, 7c, 7d, 7f, 7g and 7i have shown partial cleavage of DNA at 100 μg
concentration. The compounds 7e and 7j can be considered as DNA intercalating agents due to its planarity and
their potentiality to cleave the DNA completely. This might be through breaking the base pairs of DNA.
Keywords: DNA, Calf-thymus DNA, Thiophene, Agarose gel electrophoresis.
Keyword :
NA, Calf-thymus DNA, Thiophene, Agarose gel electrophoresis.