Abstract :
In quest of elucidating the diverse pharmacological properties of 1,3-indanedione derivatives, we have synthesized a
new series of 1,3-indanedione derivatives via Knovevanegal condensation, by condensing with the different
aldehydes (Nitro benzalyhade) to form a styrylated indane dione leading to the formation of different Schiff base.
The structures of compounds were characterized by 1H and 13C NMR, FT-IR and Mass spectral analysis. The newly
synthesized compounds are evaluated for their antioxidant (NO and DPPH scavenging, and inhibition of lipid
peroxidation), antimicrobial/antifungal, and anti-inflammatory activities. Compounds with phenolic group as the
terminal substitution or meta- and para- di-substitutions are reported with superior antimicrobial, antifungal and
anti-inflammatory activities. Compound 10 reported highest antimicrobial and antifungal activities and moderate
antioxidant activity. Anti-inflammatory activity of compound 10 is statistically similar at 50 mg/kg dose with
celecoxib (20 mg/kg). Molecular docking studies against COX2 enzyme were performed and reported similar
observations and provided deeper understanding of the ligand conformations in the protein environment.
Keywords: Indanedione, antibacterial agents, anti-oxidative, anti-inflammatory activity, molecular docking
Keyword :
Indanedione, antibacterial agents, anti-oxidative, anti-inflammatory activity, molecular docking