Abstract :
Introduction: National health & nutritional examination survey, 1988-1994, first time reported a significant positive association in iron storage & heart disease risk. Due to the scarcity of this type of study in India, we did this study to find out the relation of serum ferritin with MI
Aim: The current study attempts to evaluation association of ferritin levels at the onset of AMI & at 6 day of follow up of subjects.
Materials and Methods: A total of 39 male patients who were confirmed of having MI on the basis of lipid profile, CKMB, SGOT, SGPT, Trop I, ECG & Chest X Ray were included in the study. Serum ferritin level was estimated in study group on day 1 & day 6 of MI attack while only once in control. Serum ferritin was estimated by enzyme linked fluorescent assay on Mini Vidas auto analyzer from Biomerieux.
Results: Mean serum ferritin levels at Day-1 was not significantly elevated than controls [58.51 (±18.71) ng/ml in day-1 versus 64.09 (±19.42)]. In contrast serum ferritin levels at Day-6 were significantly elevated than controls [226.68 (±18.71) ng/ml at day-6 versus versus ferritin levels in controls (p < 0>
Conclusion: In conclusion, our data supports that elevated serum ferritin levels are associated with pathogenesis of AMI.
Keyword :
Ferritin, Myocardial infarction, AMI, iron, Inflammation, Oxidative stress, Lipid peroxidation, Ferroptosis