Hypovitaminosis D among type 2 diabetes patients and non-diabetics at Libreville


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Article type :

Original Article

Author :

Rosalie Nikiema-Ndong, Aude Syntia Mbang Bengone, Elisabeth Lendoye, Marie Lauraine Eyeng Singui, Alvine Sibylle Batou, Felix Ovono Abessolo

Volume :

11

Issue :

1

Abstract :

Background: Type 2 diabetes is resulting from insulin resistance and/or progressively reduced insulin secretion. Vitamin D nuclear receptor present on the β cells of the pancreas promotes the growth, synthesis and secretion of insulin. Furthermore, vitamin D deficiency has been associated with numerous disorders, such as type 2 diabetes, cardiovascular diseases, arterial hypertension, cancer, multiple sclerosis, depression, psychiatric diseases. Aim: Determine the frequency of hypovitaminosis D among type 2 diabetes patients and those without diabetes in Libreville. Materials and Methods: The study population was composed of 92 type 2 diabetes patients (cases) and 100 non-diabetics (controls). The vitamin D and glycated hemoglobin were performed using 25 OH Vitamin D total kit and FIA8000 kit respectively. The blood glucose, calcemia and phosphorus were performed using standard spectrophotometric assay. Results: Insufficient vitamin D ( Conclusion: High hypovitaminosis D was found among cases and controls. Therefore and in regards of studies based on vitamin D supplementation, with an appropriate concentration of vitamin D or calcitriol, glucose homeostasis may be maintained. Moreover, implementation of preventive measures should be done to avoid disastrous consequences of vitamin D insufficiency.

Keyword :

Hypovitaminosis D, Blood glucose, Calcitriol, Type 2 diabetes, Non­diabetics, Libreville