Abstract :
Chronic Kidney disease is a recognized public health problem with a huge social and economical impact
on the individual, family, society and country. Renal failure is a systemic disease and induces a slow
and progressive decline of kidney function aggravated by various factors such as diabetes, infections, auto
immune diseases and toxic chemicals.
Aim: The study was aimed to estimate malondialdehyde, urea and creatinine levels in Chronic renal failure
(CRF) patients.
Materials and Methods: The study was conducted in the department of Biochemistry, Government
medical college, Anantapuramu, Andhra Pradesh. Study subjects were divided in to 2 groups: Group -
1: healthy controls (35) with age group 35-65 years, Group -2 : CRF patients (35) age group 35 -65 years .
Blood Sample was analyzed for plasma glucose, Blood urea, serum creatinine and serum Malondialdehyde.
Results: The mean and standard deviation of Serum Malondialdehyde, blood urea and serum Creatinine
in Chronic renal failure patients (Group-2) was higher compared to controls (Group-1) (p Significant positive correlation was observed between serum Malondialdehyde and serum creatinine.
A positive correlation was observed between serum Malondialdehyde and blood urea (r= 0.40576).
Significant positive correlation existed between Malondialdehyde and serum creatinine (r=0.46832).
Conclusion: In our study on chronic renal failure patients and age matched healthy controls, the renal
parameters – urea, creatinine and BUN were elevated. In addition Malondialdehyde was found to be
significantly elevated showing a pro oxidant status in CRF patients.
Keyword :
Chronic Renal Failure CRF, Malondialdehyde MDA, Creatinine.