Author :
G. KoteshwarRao* , R.VijayaVani, M.Shiresha, B.Vidya, I.Santhosh, K. Rajeswar Dutt, and K. N. V. Rao
Volume :
5
Issue :
03
Abstract :
The objective of the present work was to develop a simple, efficient and reproducible spectrophotometric
method for the quantitative estimation of Axitinib drug in its active pharmaceutical ingredient (API) form. The
developed UV-Visible spectrophotometric method for the quantitative estimation of drug –Axitinib measurement
of absorption at a wavelength maximum (λmax) of 260 nm using methanol as diluents. The method was
validated as per the ICH guidelines. The proposed method can be successfully applied for the estimation of
Axitinib in pharmaceutical dosage forms.The linearity dynamic range 10-70 μg/ml and effective mean
percentage recoveries were 102.5% and LOQ, LOD values of Axitinib were found to be 1.62 and 5.04(µg/ml)
Key Words: Axitinib, Method Development, Validation, UV-Visible spectrophotometry.
Keyword :
Axitinib, Method Development, Validation, UV-Visible spectrophotometry.