Abstract :
The present study aims at developing an Eslicarbazepine fast dissolving tablet formulation for the effctive treatment
of Epilepsy. To provide the patient with the most convenient mode of administration, FDT’s will dissolve quickly. A
Eslicarbazepine is absorbed to atleast 90% from the gut, independently of food intake. It is quickly metabolized to
esclicarbazepine. So the present work was aimed at formulating fast dissolving tablet for Eslicarbazepine, total 6
formulations were developed by using synthetic superdisintigrants like cross caramellose sodium, Crosspovidone,
sodium starch glycolate as superdisintigrants, in a different concentration and prepared by direct compression
method and prepared tablets were evaluated for pre-compression and post-compression parameters after
conducting pre-formulation studies. All the parameters were within the pharmacopoeial limits and drug
disintigrations time was 30sec and wetting time was 38sec and the invitro dissolution showed that the drug release
was about 100.62 within 15mins in formulation (F5) containing sodium starch glycolate as superdisintigrant, based
on these parameters F5 was selected as best formulation.
Key words: Epilepsy, Crosspovidone, Sodium Starch Glycolate, Crosscaramellose Sodium, Direct Compression
Method.
Keyword :
Epilepsy, Crosspovidone, Sodium Starch Glycolate, Crosscaramellose Sodium, Direct Compression Method.