Abstract :
Background: Methicillin-resistant Staphylococcus aureus (MRSA) remains to be the most concerned pathogen with enhanced multi-drug resistance in clinical set-ups. With an immediate need to control MRSA infection, there is a steep rise in the use of mupirocin as a decolonization regime.
infection, there is a steep rise in the use of mupirocin as a decolonization regime.
Materials and Methods: A total of 65 MRSA samples were analysed in the present study. Staphylococcus infection identified by standard conventional phenotypic methods. The antibiotic susceptibility pattern of mupirocin (5 ?g/ml) was found using Kirby Bauer’s disc diffusion method and the minimum inhibitory concentration (MIC) determined using MIC E-test strips of mupirocin.
Results: All the bacterial strains presented with MIC value less than 4 ?g/ml, 23 isolates falls in the range of 0.05 ?g/ml and 0.19 ?g/ml, 12 strains MIC ranged between 0.125 and 0.640 ?g/ml. However, five MRSA isolates showed no zone against mupirocin E-strip.
Conclusions: In present study, 92% of isolates were sensitive to mupirocin, this gives hope that mupirocin can be promising in the elimination of MRSA strains, a major concern in clinical practice. Also, the use of 5µg mupirocin discs is economical as compared to mupirocin E-strips, mupirocin discs can be used in a low resourceful clinical setups. However, our study revealed no difference in sensitivity for both the E-strip and disc method.
Keyword :
Antimicrobial resistance, Methicillin- resistant Staphylococcus aureus, Mupirocin, Antimicrobials, Minimum inhibitory concentration.