Evaluation of Anti Leishmanial Activities of Withania Somnifera and Solanum Nigrum A Preliminary Study

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Abstract :

This work deals with the study of anti leishmanial activities of plant abstracts that have been evaluated for possible anti leishmanial activities using MTT Assay. In vitro inhibition was observed with chloroform growth and a similar inhibition was obtained with aqueous extract of s.nigrum and all other extracts exhibiting significant toxicity. Promastigotes of L. donovani strain AG83 were routinely cultured at 24OC in M199 medium supplemented with 10% fetal calf serum, 100 U penicillin/ml and 100 µg streptomycin/ml. The IC50 of Pentamidine was found to be 38g/ml while that for w.somnifera and s.nigrum found to be 50g/ml and 58g/ml respectively. This paper records one of the effective measures of cure of the deadly disease by medicinal plants solanum nigrum and withania somnifera against the recent drug pentamidine .

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L. donovani, anti- leishmaniasis, pentamidine, s. nigrum, w. somnifera, medicinal plants, in-vitro/in-vivo, mitochondrial dehydrogenase, formazan,
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