Abstract :
Objectives: The aim of this review is to provide brief description of synthesis, structure, properties and uses of
PAMAM dendrimers with providing some detailed examples of using PAMAM as promising drug delivery carrier.
Findings: Dendrimers as novel polymeric symmetric materials with three dimensional architecture represent a
growing substrate for drug delivery. They possess different structural and physical properties that enable them to
conjugate with different drugs to form organ-targeting drug delivery systems. PAMAM (Polyamidoamine) is the
most studied and commercially available type of dendrimers. PAMAM has been reported in different research
papers to have many pharmaceutical benefits such as solubility enhancement, permeability enhancement, gene
transfer, and organ-targeting drug delivery carrier. PAMAM has some concerns about its cellular toxicity, but many
studies suggested its biocompatibility and non-toxicity on biological tissues. Summary: PAMAM dendrimers
represent excellent promising drug delivery carrier systems with many benefits and substantial risks which require
further studying and challenging
Key words: Ciliotoxicity- Dendrimers- PAMAM- Targeted Drug Delivery.
Keyword :
Ciliotoxicity- Dendrimers- PAMAM- Targeted Drug Delivery.