Asian Journal of Pharmaceutical Technology and Innovation

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Qualitative Assessment and Investigation of Antifungal Activity of Methanolic and Petroleum Ether Extracts of Tectona Grandis Linn Seeds

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Abstract :

Tectona grandis has been claimed to be useful in treatment of microbial and fungal infections and the current literature survey revealed that no systematic approach has been made towards documentation of this claim. The currently available synthetic antimicrobial agents are associated with numerous serious side effects like hypersensitivity, crystalluria, photosensitivity, hepatic and renal damage, ototoxicity, neurotoxicity etc. These adverse effects either restrict the continuation of therapy or demand for additional drug/s to combat them. This in turn indicates the need of alternative value addition therapy. In light of this, Methanolic and Petroleum ether extract of Tectona grandis was screened for its antifungal activity by using fungal culture but none of extracts were found to be significant in this regard. The claim mentioned in an ancient period may be of value especially in absence of today’s effective antifungal agents. As far as today’s minimum standard required, it cannot be promoted as antifungal as per these observation.

Keyword :

Tectona Grandis, Methanolic and petroleum ether extract, antifungal activity, Hypersensitivity,ototoxicity,Nephrotoxicity.
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