Abstract :
Abstract Hyperthermia, a little increase in tumour temperature, increases the sensitivity ofcancer cells to radiation and chemotherapy. Getting there isn't easy, and the tried-and-trueways have their limitations. To get around some of the problems and produce tumourhyperthermia, it is possible to load tumours with energy-transducing nanoparticles that aresystematically administered. However, there are distinct obstacles that nanoparticles mustovercome before they can be used in clinical settings. Nanorods and gold nanoshells,superparamagnetic iron oxide particles, and carbon nanotubes are the three main nanoparticleformulations discussed in this article, which also provides a brief overview of the presenttechnological state of the art. Nevertheless, hyperthermia's clinical potential remainsunfulfilled, despite its promise in cancer management. This is so for a number of reasons.Traditional approaches to attaining global hyperthermia lacked standardisation, specificity, andwere inherently laborious. Even newer ways of producing hyperthermia can be intrusive andcause uneven heating inside tumours and, in rare cases, hot areas in healthy tissues aroundthem. Thanks to injectable nanoparticles like SPIONs, GNSs, and CNTs, ablative temperaturesmay now be achieved inside highly localised regions of the body while other sections remain atnormal or near-normal temperatures. This is a major breakthrough. As an alternative to themore conventional methods of tumour hyperthermia, nanoparticles show great promise. Theuse of nanoparticles in tumour hyperthermia is not without its obstacles, though. Theconsistency and sufficiency of nanoparticle buildup at the tumour site is a big concern. It is stillchallenging to achieve homogeneous temperature across the tumor's core and mantle, evenwith incredibly tiny nanoparticles. The centre of a tumour that is little vascularized is not anideal place for nanoparticles to enter consistently. Finding ways to uniformly raise temperaturein the core requires investigating other possibilities. The problem of quality control is a furtherobstacle to the clinical translation of nanoparticles. Size and compositional differences withinand between batches of laboratory-made nanoparticles are common. The likelihood of variancegrows in direct proportion to the increasing complexity of nanoparticle compositions. Usually,the zetasizer or another dynamic light scattering device is used to determine the nanoparticlesize distribution, but this method only gives an approximation of the hydrodynamic radius andnot the nanoparticles' true diameter.
Keyword :
Keywords: Gold Nanoparticle, Cancer, Techniques, Hyperthermia Techniques