Abstract :
The objective of present work was to design and develop sustained release matrix tablets of anti-hypertensive drug
Labetalol hydrochloride. Hydroxypropyl methyl cellulose K15, Sodium CMC, Xanthan gum and Tamarind seed
polysaccharide used as a rate retarding polymer. Whereas Polyvinyl Pyrrolidone and Microcrystalline cellulose are
used as granulating agent and diluent. The influence of variable concentration of polymers on the release rate of
drug was investigated. The results of the present work point out that the rate of Labetalol hydrochloride release
from polymers like Hydroxypropyl methyl cellulose K15, Sodium CMC, Xanthan gum and Tamarind seed
polysaccharide are mainly controlled by the drug–polymer ratio. The prepared sustained release matrix tablets
were evaluated for various parameters like hardness, friability, uniformity of weight, uniformity of drug content and
in vitro drug release studies.
Keywords: Hydroxypropyl methyl cellulose K15, Sodium CMC, Xanthan gum and Tamarind seed polysaccharide,
Sustained-release, Labetalol hydrochloride Formulation.
Keyword :
Hydroxypropyl methyl cellulose K15, Sodium CMC, Xanthan gum and Tamarind seed polysaccharide, Sustained-release, Labetalol hydrochloride Formulation.