Effect of intrauterine instillation of autologous platelet-rich plasma on endometrial thickness and pregnancy outcome

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Original Article

Author :

Kokila Desai, Freya Desai*, Hariom Sharma, Hitesh Bambhaniya, Shreyansh Sharma

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Abstract :

Background: Every year numerous females are detected infertile as infertility becomes a major problem in reproductive lives, worldwide. The purpose of this study is to evaluate the effectiveness of intrauterine infusion of autologous platelet-rich plasma (PRP) in infertile women undergoing frozen embryo transfer cycles with suboptimal endometrium. Material and Methods: A total of 61 women between 22 to 40 years of age were included in the study. Based on hysteroscopy findings they were divided into group A (Normal hysteroscopy findings) and group B (Abnormal hysteroscopy findings). Intrauterine instillation of autologous PRP was done in women having an endometrial thickness of ?7 even after giving Estradiol valerate therapy. After 48 and 72 hours of PRP infusion, an increase in EMT was evaluated. Embryo transfer was performed when the endometrium reached an optimal pattern in terms of thickness, appearance, and vascularity. Result: EMT increased significantly (p 0.05) in Group B compared to Group A. Between both groups, there were no apparent changes in CPR, IR, or LBR (p 0.001). Overall, clinical pregnancy and LBR increased respectively. Conclusion: Autologous platelet-rich plasma increases endometrial thickness and success rate in pregnancy after PRP administration in patients with low EMT undergoing IVF treatment and patients having two or more previous IVF failures.  

Keyword :

Endometrial thickness, Hysteroscopy, Fertility-outcome, In vitro fertilization, Embryo transfer, Intrauterine instillation, Thin endometrium, Ultrasonography.
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