The association of male infertility with telomere length: A case control study

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Original Article

Author :

Kate Deepali Rajesh*, Puranam Vatsalaswamy, Manvikar Purshotam Rao

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Abstract :

Aim: To study the relevance of sperm telomere length and infertility in men. Materials and Methods: Our case-control study included twenty-five males in couple with sub-fertility/infertility (test group) and twenty-five healthy males (control group) with proven paternity in the age group 25 to 35 years. The Absolute Sperm Telomere length (aSTL) was measured by real-time PCR. We investigated whether any significant difference in the aSTL value existed between the groups and analysed the relationship between aSTL and other sperm parameters. Results: The mean (SE) aSTL recorded in the infertile cases was significantly shorter than for the control group being 140.60 (6.66) Kb/genome and 239.63 (12.32) Kb/genome respectively (p Conclusion: The measurement of aSTL by real-time PCR is a simple and rapid method that offers further paramount information with respective to the quality of sperm. It is befitted for epidemiological studies, hence opening new perspectives in the evaluation of male infertility. Limitations - Our study was confined to men aged between 25 and 35 years. Further comparative studies are needed to explore the significance of STL and infertility in older males. Additional studies will help illumine the significance of aSTL as a prognostic biomarker in assisted reproduction.  

Keyword :

Absolute sperm telomere length (aSTL), Infertility, Real Time PCR, Spermatozoa.
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