Study of serum copper and zinc levels in type-II diabetes mellitus patients

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Original Article

Author :

Malika Noorjehan Samozai, Rajashree Devarapalli, K Ranjith Babu*

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Abstract :

Diabetes mellitus is one of the world’s most prevalent diseases. The International Diabetes Federation estimates a worldwide prevalence of 387 million (8.3%) and the global burden of Type-II diabetes is expected to increase 592 million by 2035. It is found that the trace elements like copper and zinc, which act as cofactors for the essential enzymes, which are involved in many metabolic pathways, are found to be altered in the diabetics when compared to non-diabetics. This is an observational, prospective and case-control study which is conducted to assess the levels of Cu and Zn in relation to hyperglycaemia and HbA1c in the patients with uncomplicated T2DM. Newly diagnosed uncomplicated Type-II Diabetes Mellitus patients are selected as study group. The observations were arranged in suitable tables for analysis under the relevant headings. The findings were averaged as (mean ± standard deviation) for each parameter subgroups separately. Each variable, including Serum levels of Cu (µg/dL), Zn (µg/dL), FBS (mg/dL) and HbA1C (%) were analysed by Paired Sample t-test.A number of studies with varied findings have been found stating deranged Copper and Zinc in diabetics. The levels of Cu can be measured as an early therapeutic measure of DM. It is well-known that higher levels of Cu may result in generation of free radicals through Fenton reaction, which in turn results in increased oxidative stress. Zn being important trace element for functioning of oxidoreductases, hydrolases, ligases and lyases.T2DM is related to altered levels of trace elements like Zn, Cu. Zn can be better analysed from 24 hours collected urine sample. Early detection of the trace elements Cu, Zn is very useful in early detection of onset of T2DM along with factors like FBS, HBSAg. The study can be further made more appropriate by considering more trace elements in more number of subjects for a prolonged period of study. Once the T2DM is detected early or the stage of pre-diabetes is confirmed the subject can be prevented or delayed from the chance of occurrence of Diabetic. Early detection of the trace elements Cu, Zn is very useful in early detection of onset of T2DM along with factors like FBS, HBSAg.  

Keyword :

Zinc, Copper, Trace elements, T2DM, Diabetes mellitus.
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