Neuroprotective effect of and ascorbic acid in brain against high fat diet and stress induced neurotoxicity

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Original Article

Author :

Rajesh Vaderav*, Kavitha K, Subadhra Devi Velichety, Anand Acharya

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Abstract :

Objective: Chronic exposure to stress and diet rich in saturated fat is one of the major reasons for the development of dementia and neurodegenerative disorders. The present study aims to examine the neuroprotective potential of and Ascorbic acid against high fat diet and stress induced neurotoxicity in brain. Materials and Methods: Animals were randomly divided into five groups. Group I received normal diet, Group II received high fat diet along with stress, Group III were treated with 100mg/kg body weight, and Group IV were treated with Ascorbic acid 100mg/kg body weight, Group V were treated with 100mg/kg body weight and Ascorbic acid 100mg/kg body weight. After the treatment all rats were sacrificed and brains were removed. Golgi staining was done and dendritic branching points and dendritic intersections were quantified with the help of cameralucida. Results: There was a significant increase in dendritic length and branching points was observed in brain in rats treated with and Ascorbic acid. Conclusion: Present study concludes that and Ascorbic acid have neuroprotective role against high fat diet and stress induced Wistar rats.  

Keyword :

Ginkgobiloba, Ascorbic acid, Golgi staining, Dendritic branching points, Dendritic intersections.
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