Abstract :
Background: Diabetes mellitus (DM) and thyroid dysfunctions are the two most common endocrine disorders to come across in any clinical practice. Both thyroid hormones and insulin act antagonistically in metabolic pathways or cycles of cells. The aim of our study is to look for thyroid dysfunction in patients with type 2 DM and its correlation with insulin resistance (IR).
Materials and Methods: A cross-sectional study was carried out among 325 diagnosed type 2 diabetic patients. Thyroid stimulating hormone (TSH), free triiodothyronine, free thyroxine, and insulin were measured in fasting serum sample.
Results: 325 study subjects majority 50.8% (165) belongs to age group 41-50 years followed by 28.3%(92) belongs to age group 51 -60 years while least subjects 0.9%(3) belongs to age group more than 80 years. 325 study subjects majority 58.5 %( 190) were female while rest 41.5% (153) were male. Subjects maximum 165(50.8%) have TSH level
Conclusion : The relationship between diabetes mellitus and thyroid disorders is characterized by a complex interdependent interaction. Unidentified thyroid dysfunction could negatively impact diabetes and its complications and may be one of the prime causes of poor management of type 2 DM. Therefore, there is a need for routine assay of thyroid hormones in type 2 diabetic patients to improve the medical management as well as to reduce the morbidity in them.
Keyword :
Diabetes mellitus, Insulin resistance, Thyroid hormones, Thyroidstimulating hormone.