Seroprevalence of TORCH infection and adverse reproductive outcome in women with bad obstretic history

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Original Article

Author :

Shrishti Makhijani, Sharmila S Raut

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Abstract :

Background: Aim of the study was to know the seroprevalence of TORCH infection in antenatal women with bad obstetric history and to co relate the same with different clinical presentations. Materials and Methods: IgM antibodies for TORCH infection were analyzed in the serum samples of 172 Bad obstetric history (BOH) cases attending Ante Natal clinic by using ELISA according to manufacturer’s instructions. Result: Seroprevalence for T.gondii, Rubella, CMV and HSV-2 was found to be 12.79%, 11.62%, 04.65% and 02.32% respectively. Highest seropositivity in spontaneous abortions (16.25%) and early neonatal deaths (8.33%) cases was seen with T.gondii infection. In cases with history of IUD (09.37%) and congenitally malformed babies (22.22%) maximum seropositivity was found for Rubella. History of still births (25%) was equally associated with T.gondii and Rubella infection. Conclusion: There is a need of screening programmes during antenatal visits to reduce repeated pregnancy wastages in our country. Early detection of IgM by Enzyme-linked immunosorbent assay is useful for diagnosis of TORCH infection to reduce adverse fetal outcome.

Keyword :

 TORCH, Bad obstetric history, IgM, T.gondii,Rubella, CMV and HSV-2.
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