A comparison of dexmedetomidine and clonidine premedication in perioperative hemodynamic stability and postoperative analgesia in laparoscopic cholecystectomy


Article type :

Original Article

Author :

Shreya Sharma, Shashi Prakashi, Mandeep M H Madia, Vivek Sharma, Chandramani

Volume :

7

Issue :

4

Abstract :

Background: The aim of this study was to compare dexmedetomidine and clonidine premedication in perioperative hemodynamic stability and postoperative analgesia in laparoscopic cholecystectomy. Materials and Methods: An observational study was conducted in Sir Sunderlal hospital, Banaras Hindu University. The study included ASA I-II patients undergoing laparoscopic cholecystectomy surgery. Patients undergoing general anaesthesia were included in the study. The control group received iv fentanyl, while patients in one experimental group received iv clonidine 1mcg/kg over 15 minutes, 30 minutes before and in another group received iv dexmedetomidine 1mcg/kg over 15 minutes, 30 minutes before the surgery. Heart Rate, SBP, MAP, DBP, ETCO2, PCO2 and Post-Operative Analgesia were compared for the 3 groups. Results were given as mean ± SD. Data collected were analysed using Student’s t-test. Differences were considered statistically significant if P values were Results: A total of 90 patients were included and 30 patients each were randomly assigned to one of the 3 groups. Patients who received dexmedetomidine had better haemodynamic control and post-operative analgesia. Patients who received clonidine had better haemodynamic control than control group but not better than the group who received dexmedetomidine. Conclusion: We conclude that Alpha 2 agonists specially dexmedetomidine produce diverse responses including analgesia, anxiolysis, sedation and sympatholysis.

Keyword :

 SBP, DBP, MAP, Laparoscopic surgery, Alpha 2 agonist, Dexmedetomidine, Clonidine, Haemodynamic stability.