Introduction and Aim: Colonic air bubbles and foam are major hurdle to a positive colonoscopy. Bubbles hinder mucosal visibility resulting in poor diagnostic precision. This study aimed to determine the efficacy and tolerability of Simethicone in reducing the occurrence of colonic bubbles that could interfere with colon visualization, when added to Polyethylene glycol bowel preparation regimen.
Materials and Methods: This is a prospective randomized observer blind interventional study comparing PEG vs PEG simethicone. Adult outpatients aged 18 to 60 years undergoing colonoscopy were recruited in this study. The primary outcome was the reduction in bubbles measured by intraluminal bubble score. The secondary outcome measures were patients’ tolerability and endoscopists ease.
Results: The incidence of Score 1 and 2 bubbles was much lower with PEG simethicone compared with PEG group (P
Simethicone, Polyethylene glycol, Colonoscopy, Intraluminal bubbles, Bowel preparation.