Volume :
3
Issue :
4
Abstract :
The present study was aimed to develop a novel immediate releasing drug delivery system for anti malarial drugs. The immediate release pellets loaded with solid dispersed pellets are useful in increasing the Acceptability & Palatability of children due to small size of the pellets and increased solubility of the drug. Artemether and Lumefantrine are used to treat uncomplicated malaria caused by P. falciparum in a fixed ratio dosage of (1:6). The main aim of the present study was to develop solid dispersed immediate release pellet to increase the patient compliance. The solid dispersed immediate release pellets were prepared by Extrusion and spheronization method using two super disintegrates in 4%, 6%, 8% percentages of Crospovidone and Croscarmellose sodium. The solid dispersed immediate release pellets were evaluated for compatibility, crystalline nature of the drug, uniformity of drug, friability, pellet size and in vitro dissolution studies. FTIR results indicated that there was no incompatibility between the drug and the polymers. The optimized formulation of Artemether (SDAF5) has lowest friability (0.72±0.18), pellet size (1.32±0.12). In vitro dissolution study showed that the drug release was found to be 94.55±0.58 % at the end of 60mins in 900 ml of PH 7.2 Phosphate buffer and 0.5%SLS at 37±0.5 °C. In case of Lumefantrine, The optimized formulation of Lumefantrine (SDRF5) has lowest friability (0.65±0.32), pellet size (1.29±0.45). In vitro dissolution study showed that the drug release was found to be 94.19±0.98 % at the end of 120mins in 900 ml of PH 1.2, 0.1N HCl and 0.5%Tween 80 at 37±0.5 °C. The study demonstrated that Solid dispersed immediate release pellets containing 6% of Croscarmellose sodium could be successfully formulated.