Volume :
3
Issue :
4
Abstract :
The objective of the present investigation was to prepare gastroretentive dosage form of Olmesartan Medoxomil, an angiotensin-2 receptor antagonist widely prescribed for the treatment of hypertension. Maximum absorption of the drug from the stomach favours the development of floating dosage forms of Olmesartan Medoxomil. In the present study Olmesartan Medoxomil floating tablets were prepared by effervescence method using sodium bicarbonate as a gas generating agent. The tablets were formulated using direct compression technology by employing semi synthetic polymers like various grades of HPMC such as HPMC K4M, K15M, K100M, HPC and Carbopol 934p. The prepared tablets were evaluated for various physicochemical parameters such as drug-excipient interaction by FTIR, flow properties, hardness, weight variation, friability, in vitro buoyancy (floating lag time, total floating time), swelling studies, drug content and in-vitro drug release. The in vitro drug release pattern of Olmesartan Medoxomil floating tablets was fitted to different kinetic models which showed highest regression for zero order kinetics with R2value. Out of all formulations, F9 was optimized based on desired sustained release time (16hrs) and acceptable floating properties The FTIR study revealed that there is no drug-excipient interaction.