Volume :
3
Issue :
2
Abstract :
The aim of the present investigation was to develop oral disintegrating film of sumatriptan succinate, anti migraine agent and investigate the effect of the formulation variables like concentration of film forming polymer, emulsifying agent and plasticizer on the physico chemical properties and in vitro diffusion studies. Hydroxyl propyl methyl cellulose was used as a film former, tween 80 as an emulsifying agent and glycerin as plasticizer. The three variables were studied at two level thus, a 23 full factorial design was applied and eight different formulations were developed by solvent casting method and evaluated. The role of HPMC in deciding the film properties was significant. It affected folding endurance, tensile strength, percentage elongation, disintegration time and invitro diffusion rate significantly. The in low level and tween 80 (5mg / film ie. 2x3 cm2) and PEG 4000 (8mg/fil ie. 2x3 cm2) in high level was found to be suitable for film formation with desirable physiochemical properties, faster disintegration and optimum invitro release. Here tween 80 and glycerin at high level which acted as solubility enhancers.