Volume :
3
Issue :
2
Abstract :
Oral drug delivery remains the preferred route for administration of various drugs. Recent developments in technology, led to the development of Oro-dispersible tablets (ODT’s) with improved patient compliance and convenience. ODT’s are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. Dispersible tablets disperse in water within three minutes.The faster the drug into solution, quickly will be the absorption and onset of clinical effects. Deferasirox an oral iron chelator is used in patients suffering from chronic iron over load and treatment of patients with anaemia. Deferasirox is a poorly soluble drug so, ODT’s is prepared to increase the release rate. The present work is carried out by using super disintegrants such as cross povidine, cross carmellose sodium and sodium starch glycolate(SSG). All these formulations are compressed by wet granulation technique. The developed tablets are evaluated for hardness, weight variation, friability, dispersion time, disintegration time and in -vitro dissolution studies. Before compression of the granules into tablets, the granules are evaluated for angle of repose, compressibility and hausner’s ratio. It is concluded that dispersible tablets of deferasirox (400mg) with the superdisintegrant crosspovidone, (total weight of tablet-900mg) showed rapid release rate and enhance dissolution. The developed deferasirox ODT’s has better patient compliance and effective therapy.