Volume :
3
Issue :
1
Abstract :
Nisoldipine is an antihypertensive agent. It has low absolute bioavailability (5%) is due to poorly solubility, and high hepatic metabolism in the gut wall. In this investigation of the study was to improve the oral bioavailability, superior therapeutic efficacy and improve the onset of action via Formulation and evaluation of orodispersible tablets of Nisoldipine. ODTs were prepared by direct compression method by using superdisintegrant such as Ac-di-sol, Crospovidone, sodium starch glycolate. The prepared ODTs Powder blend was evaluated for angle of repose, bulk density, tapped density, compressibility index, Hausners ratio. The prepared tablets were evaluated for weight variation, thickness, drug content, friability, hardness, wetting time, invitro disintegration time, and invitro dissolution study. The optimized formulation was found to be good hardness, wetting time, fast disintegration, and improved dissolution profile .The drug release from ODTs containing superdisintegrant was more as compared to ODTs containing without superdisintegrant and it was found to be highest (53.86±2.06% drug release after 45 min) with formulation batch containing crospovidone (F6) so it can be concluded as promising formulation.