Volume :
3
Issue :
1
Abstract :
Mouth dissolving tablet is a novel dosage form, have several characteristics to distinguish them from the more traditional dosage form. The purpose of this research was to prepare mouth dissolving tablet of tramadol hydrochloride by sublimation method with a view to enhance patient compliance. Tramadol hydrochloride is a centrally acting analgesic, which is orally and intravenously administered drug. The sublimating agent used in this study was camphor & ammonium bicarbonate, The prepared batches of tablets were evaluated for uniformity of weight, thickness, hardness, friability, wetting time, water absorption ratio, disintegration time and dissolution study. Amongst all formulations, formulation F3 prepared by 5% crosscaramellose sodium & 15% camphor showed least disintegrating time and faster dissolution.