Volume :
4
Issue :
4
Abstract :
The present research was focused on immediate release and sustained release propranolol microspheres blends for enhancing bioavailability and reduces short half-life Problem. Propranolol is a antihypertensive agent it is also used in angina pectoris. Since it has short half life, bioavailability problems the research was emphasized on preparing immediate and sustained release propranolol microspheres. Immediate release blends release the drug for quick onset of action because of presence of superdisintegrant crospovidone.. Sonication and Solvent evaporation techniques were adapted to formulate sustained release micro particles. EudragitRL-100 was taken as a polymer for preparation of microspheres. Polaxamer act as a stabilizer. Particle size was controlled by solvent precipitation method. The formulated microparticles were evaluated for drug encapsulation, invitro drug release, surface morphology, interaction study, elemental characterization study. Micro particles were characterized by SEM. FT-IR studies revealed that there was no interaction between drug and polymers used in the study. In-vitro dissolution studies were carried out for all trials. SEM study confirmed that particles are existing in micrometer level. The drug release from F5 formulation was found to zero order kinetics. It was also found linear in Higuchi’s plot which confirms that diffusion is one of the mechanisms of drug release. In this investigation optimized formulation F5 releases the drug up to 12 hours and it also fulfilled requirements such as easy to fabricate, inexpensive and high patient compliance.