Volume :
4
Issue :
2
Abstract :
Buclizine is an antihistaminic water soluble drug. The objective of the present investigation was to improve bioavailablity of buclizine oral thin film strips by using solvent casting method with excipients. Water soluble synthetic polymer (Poly Vinyl Alcohol), plasticizer (PVP), solubilizer (PEG400), carbapol, sweetener (Mannitol) was used in the preparation of oral thin film strips of buclizine. The oral thin films of buclizine were prepared by solvent casting method using 1:1 and 1:2 ratios of drug and polymers. The influence of the proportion of polymer and several co-excipients on the release rate of the drug from formulations was studied.