Volume :
5
Issue :
2
Abstract :
The present study concerns the development of floating tablets of Levofloxacin which were designed to prolong the gastric residence time after oral administration. Levofloxacin is a fluoroquinolone antibacterial agent which is highly effective against gram positive and gram negative bacteria. By applying direct compression technique floating tablets of Levofloxacin were prepared. The proportion of sodium bicarbonate was varied to get the least possible lag time, also the polymer part varied to get the desired release.The formulation developed using Hydroxy Propyl Methyl Cellulose (HPMC K100M) and Xanthan gum were used as swelling agents and sodium bicarbonate as effervescent agents. Six formulations (H1-H3 and X1-X3) were prepared and evaluated for various physical parameters, Hardness, friability, drug loading, floating ability and drug release profiles were assessed. Selected formulations were able to float immediately and showed buoyancy for at least 12 hrs. Meanwhile, sustained profiles of drug release were also obtained. All the formulation showed compliance with pharmacopieal standards. Based on the evaluation results, H3 formulation were selected as the best formulation and were checked for stability as per ICH guidelines. These results indicated that the selected formulation were stable. The drug release profile of the best formulation was well controlled and uniform throughout the dissolution studies.