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Volume :

6

Issue :

2

Abstract :

The primary objective of the present work was to evaluate the stability of the prepared Eudragit E 100 containing bioflavonoids Naringin and Hesperidin prepared by nanoprecipitation method. The nanoparticles were analyzed for the physical appearance, percentage drug content and percentage drug release. The prepared nanoparticles were subjected for long-term stability studies and accelerated stability study. The long-term stability studies were carried out for the batches FE1, FE2 and FE3 at 5⁰C±3⁰C and 30⁰C±2⁰C, 65%±5% RH for initial, 1st, 3rd, 6th, 9th and 12th month. The accelerated stability study was conducted for the formulation FE1, FE2 and FE3 at 40⁰C±2⁰C, 70%±5% RH for initial, 3rd and 6th month as mentioned in the ICH guidelines. The results depicts that the, prepared nanoparticles were stable at long term stability conditions as compared with the accelerated stability study