Volume :
2
Issue :
3
Abstract :
This study was concerned to assess the quality of different brands of Clonazepam tablets by evaluating & comparing the physico-chemical properties such as uniformity of weight, crushing strength, friability, disintegration, in-vitro dissolution of the drug along with drug content(assay). All the evaluated brands of Clonazepam tablets compiled with USP specifications for uniformity of weight, friability, crushing strength & disintegration. The amount of drug obtained & % purity was found to be less when compared to that of label claim. Among the five brands, 0.25mg & 0.5mg of Clonazepam tablets i.e., A1 & B4 was found to have more amount of drug. In the assay of Clonazepam tablets the UV method used was followedwhich is an simple, reproducible & economical method especially in the absence of high technology equipments that are not easily available in small scale laboratories.