Volume :
2
Issue :
3
Abstract :
Currently floating matrix tablets are one of the important categories of drug delivery systems with gastric retentive behavior. Ranitidine is a H2 blocker and absorbed from the upper part of GIT and hence to develop a dosage form that releases the drug in stomach so that it can be absorbed from upper part of GIT leading to improved bioavailability. Tablets of Ranitidine HCl were prepared by direct compression using different concentrations of HPMC K4M, HPMC K15M Carbopol 940, sodium bicarbonate and citric acid. Sodium bicarbonate and citric acid was incorporated as a gas-generating agent. The formulations were evaluated for pre and post compressional parameters. A combination of sodium bicarbonate (18%) and citric acid (5%) was found to achieve optimum in vitro buoyancy. The floating lag time of the prepared formulations was good >13 hours.