Volume :
2
Issue :
3
Abstract :
Aceclofenac is an anti-inflammatory and analgesic agent. For inflammatory conditions of eye a prolonged action pharmaceutical may be recommended. The present work aims to prepare a sustained release nanosuspension of aceclofenac using Eudragit RS 100 by quasi-emulsion solvent diffusion technique. The resulting nanosuspensions showed interesting mean sizes for ophthalmic appilications. The particle size can be influenced by various process and parameters, such as drug concentration of stabilizers, cooling conditions, and homogenization procedure. Further it has shown that formulating aceclofenac as a nanosuspension is highly successful in sustained release of drug. Particle size was found using Atomic force microsope(AFM) and the average particle size was found to be73.27 nm. Invitro drug release studies are carried out using dialysis membarane with 12,000 cut off value. The drug release studies was found to be decreasing with increase in the percentage of the drug polymer ratio. The formulation B2with drug polymer ratio (2:3) was found to be having thee higher retardation capacity.