Volume :
2
Issue :
3
Abstract :
Pioglitazone hydrochloride is an oral anti diabetic drug. It is poorly soluble in water. In the present investigation an attempt was made to increase the solubility and dissolution of Pioglitazone by preparing β-cyclodextrin complexes in different ratios. Prepared inclusion complexes were evaluated for angle of repose, Carr’s index, Hausner’s ratio and in vitro dissolution studies. The in vitro dissolution studies had shown that the complexes containing pioglitazone hydrochloride: β cyclodextrin in 1:10 ratio had shown better enhancement in dissolution rate when compared with other ratios.