Volume :
2
Issue :
2
Abstract :
Two simple, rapid, precise and reproducible UV spectroscopic methods has been developed for simultaneous estimation of two component drug mixture of Levocetirizine(LEVEC) and Ivermectin(IMEC) in bulk and combined tablet dosage form. The method employs the application of simultaneous equation. All these methods utilize 1:1 of acetonitrile and water as a solvent. LEVEC shows maximum absorbance at a wavelength of 230 nm and IMEC at 245 nm, where the linearity ranges for LEVEC and IMEC were 1.0-6.0 μg/ml and 1.2-7.2 μg/ml, respectively. The procedures were successfully applied for the simultaneous determination of both the drugs in laboratory prepared mixtures and in tablet preparation. The accuracy of the methods was found to be ranging from 97.75-100.9% for LEVEC and 98.85-99.43% for IMEC respectively, the relative standard deviation was found to be 0.5974 and 0.4096 with excellent precision and accuracy. Assay results were in good agreement with label claim.