Volume :
2
Issue :
1
Abstract :
Present investigation is aimed to develop a Novel cream formulation consisting of a combination of Hydroquinone,Tretinoin and Mometasone Furoate (4.0%+0.05%+0.1%)w/w as a Depigmenting agent for the treatment of skin disorders like Hyperpigmentation and Melasma due to its wide spectrum of activity and low toxicity.Pigmentary disorders are noncontiguous skin disease, which can be prevented by administration of drugs through topical route having the ability to deliver a higher concentration of drug to the skin than would be possible with systemic therapy. This study aims to develop the triple combination cream due to the additive and synergistic effects of the three components. As there is no topical formulation in combined form, a such formulation of cream is prepared by using multi-ingredients. To assess the efficacy of formulations, assay, drug release, microbial activity, rheology, stability, spreadability, permeability and other physical characteristics were evaluated.One formulation containing Sodium Benzoate as preservative showed desired physico-chemical characteristics amongst all the formulations.